Table of Contents
Cellular Biology
Cells are the smallest living units of an organism. https://www.youtube.com/watch?v=URUJD5NEXC8
All cells have
- membrane, separates cell interior from the environment
- cytoplasm, jelly-like fluid
- DNA, the cell's genetic material
Eukaryotic cell
- advanced, complex, contains organelles, including nucleus
- examples: plants, animals, fungi
Prokaryotic cell
- simple, no organelles, no nucleus
- always unicellular
- examples: bacteria
organelle = “little organ”, specialized function
nucleus - an organelle, has a membrane, contains DNA
DNA - dictates what the cell will do, and how it's going to do it
chromatin - the tangled, spread out form of DNA
chromosomes - When a cell is ready to divide, the DNA condenses into structures known as chromosomes.
nucleolus - a structure inside the nucleus where ribosomes are made
ribosomes - have the job of synthesizing proteins. Float around in the cytoplasm outside the nucleus.
endoplasmic reticulum (ER) -
mitochondria
Bacteria
https://www.youtube.com/watch?v=b15Hy3jCPDs
among the oldest living organisms
bad ones cause cholera, TB, plague, and others
unicellular prokaryotes
smaller than plant and animal cells
found everywhere in the environment
different shapes and sizes
does not have a nucleus, but does have a nucleoid
nucleoid - bacteria's version of a nucleus. DNA floats in the cytoplasm in an area known as the nucleoid
bacteria have two types of DNA: plasmid and chromosomal
cell wall - bacteria has a cell wall, like plants, unlike animals
flagellum - whip-like structure for locomotion
10 times more bacteria cells than human cells in the human body
- 37.2 trillion human cells in the human body
- 370.2 trillion bacteria cells in the human body (10x)
Ninja Nerd: Cell Cycle: Interphase & Mitosis https://www.youtube.com/watch?v=LUDws4JrIiI&list=PLTF9h-T1TcJi_1FdKlH4dbf_3uI4wuT99
Human cells
- membrane or “wall”
- nucleus, containing DNA
- cytoplasm
- organnelles
mytosis - cycle through which cells replicate
amytotic cells do not replicate
Three types of cells:
- Labile - replicating all the time: skin, GI tract, urinary tract
- Stable - liver
- Permanent - do not replicate, nerves, skeletal muscles
Cell Structure
Khan Academy, Cell Theory, Cell Structure https://www.youtube.com/watch?v=Hmwvj9X4GNY
- cellular membrane
- nucleus
- membrane
- nucleolus - densely packed bundle of proteins, ribosomal RNA is produced here
- DNA
- chomatin
- proteins
- cytosol
- ribosomes - translate mRNA into proteins, made of ribosomal RNA
- endoplasmic reticulum - tunnels lead from nucleus to Golgi bodies, ribosomes attached. These ribosomes output proteins into the tunnel so they can exit the cell.
- Golgi bodies
- organelle - membrane-bound subunit of a cell
- vesicles - clump of protein surrounded by membrane, floating around in the cell. It can float to the cell wall where the membrane can merge with the cellular membrane allowing the protein to exit the cell.
- lysosomes (animal) - contain enzymes that dissolve other things.
- lytic vacuole (plant) - same purpose as lysosome
- mitochrondria - cellular respiration, where sugars are turned into ATP. Contain their own DNA and can reproduce on their own. Speculation: at one time, mitochondria may have been independent prokaryotes and later decided to live within a cell.
- chloroplasts (plant) - photosynthesis, likewise has their own DNA and ribosomes
- cell wall (plant, non-animal) - celulose, adds strength to cellular membrane
- actin filaments - add structure to cell, facilitate transportation within the cell
- microtubules - ?
- centrioles - microtubules
- prokaryote
- bacteria
- archaea
- eukaryote
- plants
- animals
- fungi
DNA, transcribed into mRNA, translated by the ribosomes into proteins
Mitochondria
Khan Academy, Mitochondria https://www.youtube.com/watch?v=i1dAnpSFbyI
mitochondrion, singular from of mitochondria
a membrane-bound organelle, much like the Eukaryote
ATP factory, releases energy used in the body for movement, thinking, etc.
in ATP form, you have adenosine triphosphate. Remove one of the phosphate groups, energy is released.
glucose
lots of mitochondria in the muscles
At one time, mitochondria were independent organisms, like bacteria. Now living in symbiosis inside a cell.
outer membrane
- phospho lipids - outer membrane of the mitochondria
- porins - proteins, holes in the outer membrane, so some cells can pass thru
inner membrane
- phospho lipid
- folds to increase surface area, crista (singular), cristae (plural)
intermembrane space
- electron transport chain
- ATP synthase
glycolysis occurs in cytosus