Table of Contents
Molecular Biology
Amino Acid
Protein
“Ron Vale (UCSF, HHMI) 1: Molecular Motor Proteins” on YouTube https://youtu.be/9RUHJhskW00 1674 Loewenhoek microscope
“From DNA to Protein” on YouTube https://youtu.be/D3fOXt4MrOM
“What is a Protein?” on YouTube https://youtu.be/wvTv8TqWC48 There are 21 amino acids, all made of carbon, hydrogen, nitrogen, oxygen. Some contain sulphur.
One amino acid contains a selenium atom.
An amino group, a carboxyl group, and a side chain, all attached to a single carbon atom. The side chain determines the amino acid's properties and is the only part of the molecule that varies.
Hydrophobic Hydrophilic Charged
Structure
Primary A linear sequence of amino acids as encoded by dna.
Peptide bonds. The amino group of one amino acid links to the carboxyl group of another. A water molecule is released each time a peptide bonds is formed. This linked series of carbon, nitrogen and oxygen atoms is the protein backbone.
Secondary
Often fold into one of two secondary structures:
Alpha helix - Right-handed coil stabilized by hydrogen bonds between amino and carboxyl group of nearby amino acids.
Beta sheet - hydrogen bonds stabilize two or more adjacent strands of amino acids.
Tertiary
The three dimensional structure
“Life Science - Protein synthesis (Translation)” on YouTube https://youtu.be/kmrUzDYAmEI
RNA
DNA
Nucleic Acid
Central dogma
The Central Dogma https://youtu.be/J3HVVi2k2No